內容簡介
本書被譽為”神經科學聖經”“神經科學教科書金標準”,凝聚了眾多權wei神經科學家的主要、前沿的研究,從神經系統的分子、細胞、解剖結構一直到感覺、運動、認知功能,系統、全面地詮釋了腦是如何控制全身各器官、系統功能以及適應環境的行為的,並展示了人們對各種神經、精神疾病生物科學基礎的新認識。本書為各領域神經科學工作者和學生提供了一份很有價值的指南。對於想要不斷深化對腦、精神意識及行為的理解或想要長期從事”探索腦”的工作的讀者,本書是權wei指導。
作者簡介
埃裡克 坎德爾(Eric R Kandel)1929年出生於奧地利的維也納,1956年畢業于美國紐約大學,獲醫學博士學位。1983年至今任哥倫比亞大學生物化學與分子生物物理學系教授、霍華休斯醫學研究中心高級研究員。2000年獲諾貝爾生理學或醫學獎。
目錄
Part I
Overall Perspective
Part II
Cell and Molecular Biology of Cells of the Nervous System
Part III
Synaptic Transmission
Part IV
Perception
Part V
Movement
Part VI
The Biology of Emotion, Motivation, and Homeostasis
Part VII
Development and the Emergence of Behavior
Part VIII
Learning, Memory, Language and Cognition
Part VIII
Learning, Memory, Language and Cognition
前言/序言
As in previous editions, the goal of this sixth edition of Principles of Neural Science is to provide readers with insight into how genes, molecules, neurons, and the circuits they form give rise to behavior With the exponential growth in neuroscience research over the 40 years since the first edition of this book, an increasing challenge is to provide a comprehensive overview of the field while remaining true to the original goal of the first edition, which is to elevate imparting basic principles over detailed encyclopedic knowledge
Some of the greatest successes in brain science over the past 75 years have been the elucidation of the cell biological and electrophysiological functions of nerve cells, from the initial studies of Hodgkin, Huxley, and Katz on the action potential and synaptic transmission to our modern understanding of the genetic and molecular biophysical bases of these fundamental processes The first three parts of this book delineate these remarkable achievements
The first six chapters in Part I provide an overview of the broad themes of neural science, including the basic anatomical organization of the nervous system and the genetic bases of nervous system function and behavior We have added a new chapter (Chapter 5) to introduce the principles by which neurons participate in neural circuits that perform specific computations of behavioral relevance We conclude by considering how application of modern imaging techniques to the human brain provides a bridge between neuroscience and psychology The next two parts of the book focus on the basic properties of nerve cells, including the generation and conduction of the action potential (Part II) and the electrophysiological and molecular mechanisms of synaptic transmission (Part III)
We then consider how the activity of neurons in the peripheral and central nervous systems gives rise to sensation and movement In Part IV, we discuss the various aspects of sensory perception, including how information from the primary organs of sensation is transmitted to the central nervous system and how it Preface is processed there by successive brain regions to generate a sensory percept In Part V, we consider the neural mechanisms underlying movement, beginning with an overview of the field that is followed by a treatment ranging from the properties of skeletal muscle fibers to an analysis of how motor commands issued by the spinal cord are derived from activity in motor cortex and cerebellum We include a new treatment that addresses how the basal ganglia regulate the selection of motor actions and instantiate reinforcement learning (Chapter 38)
In the latter parts of the book, we turn to higherlevel cognitive processes, beginning in Part VI with a discussion of the neural mechanisms by which subcortical areas mediate homeostatic control mechanisms, emotions, and motivation, and the influence of these processes on cortical cognitive operations, such as feelings, decision-making, and attention We then consider the development of the nervous system in Part VII, from early embryonic differentiation and the initial establishment of synaptic connections, to their experience-dependent refinement, to the replacement of neurons lost to injury or disease Because learning and memory can be seen as a continuation of synaptic development, we next consider memory, together with language, and include a new chapter on decisionmaking and consciousness (Chapter 56) in Part VIII
Finally, in Part IX, we consider the neural mechanisms underlying diseases of the nervous system
Since the last edition of this book, the field of neuroscience has continued to rapidly evolve, which is reflected in changes in this edition The continued development of new electrophysiological and light microscopic–based imaging technologies has enabled the simultaneous recording of the activity of large populations of neurons in awake behaving animals These large data sets have given rise to new computational and theoretical approaches to gain insight into how the activity of populations of neurons produce specific behaviors Light microscopic imaging techniques using genetically encoded calcium sensors allow us to record the activity of hundreds or thousands of defined classes of neurons with subcellular resolution as an animal engages in defined behaviors At the same time, the development of genetically encoded light-activated ion chan